Rilpivirine → West Nile Fever
💊 Rilpivirine
🎯 West Nile Fever
7.2/10
Original Indication
Antiretroviral (HIV treatment)
Proposed New Indication
Repositionnement de la Rilpivirine, un inhibiteur non-nucléosidique de la transcriptase inverse (NNRTI), pour le traitement de la fièvre du Nil occidental, ciblant la réplication virale.
Proposed Mechanism
Targets: West_Nile_Virus_RNA_Dependent_RNA_Polymerase
La Rilpivirine inhibe l'activité de l'ARN polymérase dépendante de l'ARN (RdRp) du virus du Nil occidental, essentielle à la réplication virale.
Evidence
Level: In vitro et en culture cellulaire
Source: García-Zarandieta, M., et al. (2023). Identification of West Nile virus RNA-dependent RNA polymerase non-nucleoside inhibitors by real-time high throughput fluorescence screening. Antiviral Res, 212, 105568.
Reference: PubMed 36842536
Repurposing Score
6.0
Evidence
8.0
Feasibility
5.0
Market
10.0
Competition
8.0
Originality
7.19
Composite Score · HIGH POTENTIAL
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